ITGA2B and Thrombocytopenia: Monoclonal antibodies against conformational epitopes in GPIIb/IIIa- or anti-GPIIb/IIIa-specific inflammatory reactions could induce irreversible thrombocytopenia, hematocrits decrease, hypothermia, acute systemic reactions, and a paradoxical loss of surface GPIIb/IIIa on platelets in vivo. The loss of surface GPIIb/IIIa implied the formation of platelet-derived microparticles36.