Among these four modules, most mRNAs were found to have been enriched in VEGF signaling pathway, pathway in cancer, TGF-beta signaling pathway, MicroRNAs in cancer, MAPK signaling pathway, mTOR signaling pathway, and colorectal cancer pathway; all these pathways are closely related to the occurrence and development of tumor (Fig. 4A–D). The gene discussed is VEGFA; the disease is cancer.