Further, while there was no significant difference in the overall number of PD-1+FoxP3+CD25+CD4+ Tregs between healthy controls and uveitis patients following A2Ar stimulation with CGS21680, there were more uveitis patients that showed an increase over two-fold compared with healthy controls, and the body mass index appears to correlate with the responders. The gene discussed is CD4; the disease is uveitis.