CTLA4 and neoplasm: In addition, checkpoint inhibitor-based immunotherapies targeting the regulatory pathways of T cells, cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) (ipilimumab) and programmed cell death protein 1 (PD-1) (e.g., nivolumab or pembrolizumab), have enhanced anti-tumor activity with significant clinical benefit in patients with various cancers48 including HCC49.