These include: TRIP13, a mitosis regulator that was shown to promote tumor growth in colorectal cancer34 and is a predictor of poor prognosis in prostate cancer35; ORAOV1, a gene overexpressed in many solid tumors that is linked to generation of reactive oxygen species36; TPX2, an interactor and substrate of Aurora-A that is a potent oncogene amplified in many cancers and a promising therapeutic target37,38; and DUSP22, which has been shown to behave as a tumor suppressor gene in peripheral T-cell lymphomas39 and regulates ERα dependent transcription in breast cancer cells40. Here, LTO1 is linked to breast cancer.