Among the 65 Rank-1 cis genes (Supplemental Table S4), known cancer drivers included MCL1, ACTL6A, MYC, CCND1, FOXA1, ERBB2, CCNE1 (oncogenes in amplifications) and RPL5, ZMYND10, KMT2C, CSMD1, CDKN2B, PTEN, CREBL2, FANCA and ARHGAP35 (tumor suppressors in deletions) (Supplemental Table S5). The gene discussed is RPL5; the disease is cancer.