Remarkably, among the top 15 Rank-1 cis genes, 14 genes were known cancer drivers (PTEN, WWOX, CCNE1, CDKN2A, MAP2K4, EGFR, KAT6A, MYC, KRAS, ERBB2, WHSC1L1, PARK2, CREBBP, RB1) and only 1 was unverified (ATP9B) (Fig. 4B, left) (Fisher’s exact test P-value = 7.76e-08). The gene discussed is RB1; the disease is cancer.