Studies by Jia et al15, and confirmed by us, demonstrate the requirement for OPG expression to develop the full PAH phenotype in the mouse SuHx model (Supplementary Figure 1), we also demonstrated the increase of OPG expression with development of PAH in the monocrotaline rat model (Supplementary Figure 2). Here, TNFRSF11B is linked to pulmonary arterial hypertension.