These observations suggest that, similarly to CD274-MIRB and CD274-FLAM_A, variants 9 and 12 were sporadically expressed in our sample collection or in independent cohorts (Gong et al., 2019) and that CD274-L2A is the predominant sPD-L1-encoding variant in the majority of tumour and healthy samples. This evidence concerns the gene SPDL1 and neoplasm.