The function of sclerostin is indicated by sclerosteosis (MIM 269500) and Van Buchem Disease (hyperostosis corticalis generalisata; OMIM 239100; Hernandez, Whitty, John Wardale, & Henson, 2014; Kusu et al., 2003), both of which are genetic disorders of high bone mass. The gene discussed is SOST; the disease is hyperostosis corticalis generalisata.