Accumulative evidences indicate that targeting inflammasome pharmacologically may salvage penumbral tissue in cerebral ischemia.68, 69 Remarkably, the NLRP3 inhibitor MCC950 and the NLRP1 neutralizing antibodies have been proved to be curative in ischemic stroke.70 Besides, repressing inflammasome through enhancing autophagy has also been proved to offer protection in ischemic stroke.71 Inhibiting inflammasome to limit excessive neural inflammation in acute ischemic stroke should be a promising therapeutic strategy, which needs further efforts for clinical translation. This evidence concerns the gene NLRP1 and ischemic stroke.