Similar conflicting results are also observed in enchondroma and central chondrosarcoma: an immunohistochemistry study on 101 primary tumours shows high levels of the H3K4me3, H3K9me3 and H3K27me3 histone modification marks, irrespective of the IDH1 or IDH2 mutation status [67]. Here, IDH2 is linked to chondrosarcoma.