First, the high ratio of macrophages might be achievable in the tumor environment where macrophages reportedly reside in high ratios.45 Second, while this technique may not be beneficial for delivering a therapeutic that required near universal transfer for effect (i.e., p53, KRAS), it would be useful for delivering therapeutics that can alter the tumor microenvironment (i.e., matrix metalloproteinases, TBF‐beta). This evidence concerns the gene KRAS and neoplasm.