The authors evaluated the diagnostic value of plasma exosomal SOX2-OT in distinguishing LSCC from non-LSCC and reported that its AUC, sensitivity, and specificity were 0.815, 76%, and 73.17%, respectively.121 Similarly, a study reported that serum exosomal lncRNA MALAT-1 was more highly expressed in NSCLC patients than in healthy controls, and ROC curves indicated that the AUC, sensitivity, and specificity were 0.703, 0.601, and 0.809, respectively, when serum exosomal MALAT-1 was tested as a diagnostic biomarker for NSCLC.122. This evidence concerns the gene SOX2 and non-small cell lung carcinoma.