A recent study revealed that exosomal miR-499a-5p had higher expression in highly metastatic lung cancer cells than in weakly metastatic lung cancer cells and that exosomal miR-499a-5p from highly metastatic cancer cells led to EMT in recipient cancer cells by increasing the expression of p-S6K1 and p-4E-BP1, which implied activation of the MTOR pathway. The gene discussed is EIF4EBP1; the disease is lung cancer.