In addition, this serum biomarker (AUC 0.822, sensitivity 63.16%, specificity 80.00%) also showed better diagnostic power than did CEA (AUC 0.718, sensitivity 50.37%, specificity 85.00%) in detecting early-stage NSCLC.120 Another study revealed that plasma exosomal SOX2-OT and ENSG00000245648 were upregulated in plasma exosomes from lung squamous cell carcinoma (LSCC) patients compared with those from negative controls. The gene discussed is SOX2; the disease is non-small cell lung carcinoma.