Furthermore, the packaging of H19 into exosomes was revealed to be mediated by heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1).129 The key role of exosomal lncRNAs in drug resistance acquisition by lung cancer cells may offer a clue for approaches aiming to reduce the possibility of chemotherapy failure in lung cancer. This evidence concerns the gene H19 and lung carcinoma.