In order to obtain a better insight regarding the possible role of LoF ZnT1 mutations in cancer initiation and progression, and in order to render these LoF ZnT1 mutations potential cancer driver mutations, we explored the impact of these mutations on cellular zinc homeostasis in non-malignant human embryonic kidney HEK293 cells which harbor an intact zinc homeostasis. Here, SLC30A1 is linked to cancer.