Among these, known drivers of renal fibrosis including TGF-β, Wnt, and EGFR/ErbB signaling stand out.21–23 The TGF-b and EGFR/ErbB pathways are significantly over-represented in CARNIVAL with clear directionality while Wnt and TGF-β pathways are ambiguous in GSEA (Supplementary Table S5). The gene discussed is EGFR; the disease is renal fibrosis.