Wnt signaling was reported as a dysregulated process in CARNIVAL and is known to be involved in podocyte injury and renal fibrosis.22 The IgAN network included representative mediators of the classical Wnt signaling pathway from the messenger WNT7A to the TFs TCF4 and TCF7, although it should be noted that not all of these are linked in the expected ways nor do all members show the expected activity. The gene discussed is TCF7; the disease is renal fibrosis.