WB assessment of xenograft tumor tissues revealed that levels of p-AKT (s473), HIF-1α and VEGFA in tumor tissue from the CDK5RAP3 overexpression group was less than in the control group (Fig. 4f), while levels of p-AKT (s473), HIF-1α and VEGFA in tumor tissue from the knockdown group was more than that in the control group (Fig. 4g). The gene discussed is HIF1A; the disease is neoplasm.