Our transcriptional investigations indicate that the balance between extra-cellular matrix (ECM) production and degradation is dysregulated in both NASH models, but genes involved in ECM remodeling (TIMPSs and MMPs), ECM production (Collagens) as well as in HSC activation (Osteopontin) are more dysregulated in MCD-fed mice than in ATH-fed mice. The gene discussed is SPP1; the disease is metabolic dysfunction-associated steatohepatitis.