Generally, it is thought that IgM monoclonal gammopathy is associated with peripheral neuropathy presenting as distal acquired, demyelinating, symmetric neuropathy with M protein (DADS-M)8,18, while non-IgM monoclonal gammopathy patients show a more diverse phenotypes including the length-dependent sensorimotor axonal peripheral neuropathy19. This evidence concerns the gene CD40LG and peripheral neuropathy.