IDH1 and cancer: However, while the number of hypermethylated probes was ~100,000 in most of the cancers, acute myeloid leukemia (AML) showed the most prominent hypermethylation phenotype with 122,648 hypermethylated probes and the highest level of tumor specific hypermethylation (Fig. 2b, Table 1), validating the findings observed in IDH1/2 mutant vs wild-type leukemia analysis (Fig. 1a,b).