Interestingly, IDH mutated AML compared to normal blood showed the highest number of differentially hypomethylated promoter probes compared to IDH mutated vs wild-type AML, oligodendroglioma vs RTKI GBM and astrocytoma vs Classic/Mesenchymal (Fig. 1, Supp. The gene discussed is IDH1; the disease is acute myeloid leukemia.