CXCL5, which encodes an epithelial cell-derived neutrophil activating peptide (also called ENA-78), has previously been suggested as a possible candidate gene for inflammatory diseases36,37 Since the previously mentioned variants, rs425535 and rs352046, have been shown to be associated with higher CXCL5 plasma concentrations and higher CXCL5 expression levels respectively, this further indicates that these variants might play a role in the pathogenesis of IBD. The gene discussed is CXCL5; the disease is inflammatory bowel disease.