Statistical analysis of four models in HCC tissues show significant increases in AUC ratios and corresponding p-values, respectively, compared to the ratios and p-vales in a whole collection of liver cancers (TIPRL and LC3, AUC 62.8%, p = 0.08; CD133, AUC 69.5%, p = 0.007; TIPRL/LC3/CD133, AUC 64.%, p = 0.04). The gene discussed is PROM1; the disease is hepatocellular carcinoma.