CYP11B2 and familial hyperaldosteronism type II: The model described herein reproduces features of FH-II in humans, albeit with a less severe phenotype than in human index cases: elevated aldosterone levels associated with a mild increase in blood pressure and incomplete suppression of aldosterone synthase expression upon high-salt challenge (1.71% sodium diet, corresponding to the very high end of the spectrum of human salt consumption46,47).