PROS1 and Alzheimer disease: At 6 days after the injection of clodronate liposomes, serum PROS1 levels were significantly decreased in 5XFAD mice compared to 5XFAD mice injected with control liposomes (Supplementary Fig. S10b), indicating that the secretion of PROS1 from microglia affects serum PROS1 levels, reflecting the pathogenesis of AD.