Moreover, two neuroimaging biomarkers, global amyloid retention and hippocampal volume area, were highly correlated with serum PROS1 levels in both the AD dementia group and PiB-PET(+) subjects, indicating that both amyloid pathology and hippocampal atrophy due to neuronal death could be represented by serum PROS1 levels. The gene discussed is PROS1; the disease is hippocampal atrophy.