PSEN1 and Alzheimer disease: To verify whether the 5XFAD mouse model and age-matched hippocampal proteome data could be applied to further AD studies, we assessed the commonality between the alterations of the proteome in the 5XFAD mouse model and other AD transgenic mouse models, including hAPP transgenic mice with the Swedish and Indiana mutations in human APP and hAPP/PS1 transgenic mice with the Swedish mutation in human APP and human PSEN1 deltaE98.