As shown by the results, IGFL2-AS1, AC023043.1, AP000439.2 and AC124854.1 were upregulated in tumor cells and tissues, while AL355102.4, TMEM246-AS1, AL133467.3, ZNF582-AS1, LINC01510 and PSMG3-AS1 were downregulated in KIRC cell lines and tumors. The gene discussed is COMETT; the disease is neoplasm.