ARNT, CTCF, POLR2A, RAD21 and REST were downregulated in kidney cancer samples and indicated poor prognosis when lowly expressed, which revealed that ARNT, CTCF, POLR2A, RAD21 and REST tended to be risk factors with lower gene expression (Supplementary Figure 24B, 24D, 24E, 24F, 24H). The gene discussed is ARNT; the disease is kidney cancer.