Weng W, et al. suggested that piR-1245 target a group of tumor suppressor genes include ATF3, BTG1, DUSP1, FAS, NFKBIA, UPP1, SESN2, TP53INP1 and MDX1, hence, piR-1245 play a carcinogenic role and may serve as potential prognostic biomarker in colorectal cancer [52]. Here, PIR is linked to neoplasm.