Mai D, et al. revealed that piRNA-54265 play an oncogenic function and might be a therapeutic target in CRC by promoting the formation of PIWIL2/STAT3/phosphorylated-SRC (p-SRC) complex, which activates STAT3 signaling and promotes proliferation, metastasis and chemoresistance of CRC cells [54]. Here, STAT3 is linked to colorectal carcinoma.