FOXA1 and breast carcinoma: Among the 22 breast cancer-related traits, 4 are enriched in predicted essential enhancers with statistical significance (FDR < 20%; Fig. 5 G and H), and “breast cancer (early onset)” is the top trait, followed by “breast cancer (survival).” Enhancers bearing these SNPs have higher predicted essential scores compared with random DNase I-hypersensitive sites or ER or FOXA1 binding sites (SI Appendix, Fig. S10G).