NFKB1 and HIV-associated nephropathy: Relevant to this, kidneys from the Notch4d1/Tg26+ mice showed a significant decrease in expression of the inflammatory cytokines Il-6 and Ccl2, as well as the inflammatory transcription factor Nfkb1. These findings imply that Notch4 activation is one of the major determinants of increased inflammation in HIVAN.