The CD49d+CD11b− N1 neutrophils isolated from SCIDbg mice with mild systemic inflammatory response syndrome (SIRS) secrete the cytokine IL-12 and chemokine CCL3, while CD49d−CD11b+ N2 neutrophils isolated from SCIDbg mice with severe SIRS mainly produce IL-10 and CCL2. The gene discussed is CCL3; the disease is systemic inflammatory response syndrome.