Importantly, while WT mice exhibited neuroprotection on PSD3 following acute post-stroke IV IL-1α treatment (infarct volume WT vehicle: 18.99 ± 2.50 mm3 vs. WT IL-1α: 3.65 ± 0.8921 mm3 one-way ANOVA p < 0.001), IL-1α was not neuroprotective in pln KO mice (infarct volume pln KO vehicle: 23.38 ± 1.99 mm3 vs. pln KO IL-1α: 26.36 ± 3.50 mm3p < 0.5) (Fig. 4a, b). This evidence concerns the gene PLN and stroke disorder.