One study reported a significant increase in CD18+CD11c− and CD18+CD2− NK cells in ME/CFS patients compared with HC [17], while another reported a significant decrease in CD56BrightCD2+CD18+ and CD56DimCD18+CD11a+CD11c+ NK cells [21]. This evidence concerns the gene ITGB2 and myalgic encephalomeyelitis/chronic fatigue syndrome.