Receiver operating characteristics (ROC) curves illustrate the ability of the individual markers C9orf50 (area under the curve (AUC) = 0.86), KCNQ5 (AUC = 0.91) and CLIP4 (AUC = 0.88) to discriminate CRC patients from controls (Fig. 4b–d, Additional file 6: Figure S6). This evidence concerns the gene KCNQ5 and colorectal carcinoma.