Thirty-nine TFs were predicted to bind to the P1 promoter on the PROMO website [41, 42] and 469 genes who showed co-expression with CD274 with correlation coefficients more than 0.3 were screened out from the cBioportal website (HCC, TCGA, Provisional) [43, 44]. This evidence concerns the gene CD274 and hepatocellular carcinoma.