Since we established that HSP-specific T-cells are pro-inflammatory in both patients and healthy controls, and that the co-expression of LAG3 and CD49b can be used to identify tolDC-activated antigen-specific Tr1 cells, we used these markers to study whether tolDC induced a Tr1 phenotype in HSP-specific T-cells of IA patients. This evidence concerns the gene ITGA2 and hereditary spastic paraplegia.