In the present study, we found that 1) the textural analysis based on T2 weighted images had robust value in differentiating KRAS status in rectal cancer; 2) rectal cancers with KRAS mutation showed lower ADC value and manifested as ulcerofungating/ ulceroinfiltrative mass or had bulky shape, behaving more aggressive to surrounding tissue with larger MEMD and higher T stage. Here, KRAS is linked to rectal cancer.