FOXO3 and nasopharyngeal carcinoma: Importantly, SIRT2 inhibition or silencing can combine with Lapatinib to cause further enhancement of FOXO3 acetylation than Lapatinib treatment alone in both sensitive and resistant NPC cells, suggesting that SIRT2 can moderate the cytotoxic functions of Lapatinib and promote resistance through limiting FOXO3 acetylation.