AK1 and nasopharyngeal carcinoma: However, overall the SIRT2 inhibitors AGK2 and AK1, but not the SIRT1 and pan-SIRT inhibitors, demonstrated additive antiproliferative effects on Lapatinib in SRB cell proliferative assays, suggesting that SIRT2 plays a specific role in limiting Lapatinib cytotoxicity and in promoting Lapatinib resistance in NPC cells.