AK1 and nasopharyngeal carcinoma: To ascertain further the role of SIRT2 in enhancing Lapatinib resistance in NPC cells, we performed clonogenic survival assays on the two NPC cell lines to study the long-term antiproliferative effects of the two SIRT2 inhibitors AGK2 and AK1 on Lapatinib (Fig. 6a).