By contrast, upon Lapatinib treatment the expression levels of SIRT2 remained constitutively high in the resistant 5-8F cells, but were downregulated by Lapatinib in the sensitive 6-10B cells, suggesting that SIRT2 can potentially mediate Lapatinib response through modulating FOXO3 acetylation and activity in these NPC cells. Here, FOXO3 is linked to nasopharyngeal carcinoma.