ERBB2 and nasopharyngeal carcinoma: However, although EGFR1/HER2 inhibitors have previously been shown to modulate p38 and JNK activity [41, 42], we did not observe any substantial changes in p38 and JNK phosphorylation/activity in NPC cells in response to Lapatinib treatment, suggesting it is unlikely that Lapatinib modulates FOXO3 activity via p38 and JNK in these NPC cells.