Inhibition of SIRT2 by chemical inhibitor or silencing significantly enhances the cytotoxicity of Lapatinib not only in the sensitive but also in the resistant NPC cells, suggesting that SIRT2 not only modulates the cytotoxic functions of Lapatinib in the sensitive NPC cells, but it also mediates Lapatinib resistance. The gene discussed is SIRT2; the disease is nasopharyngeal carcinoma.