Although our findings show that all four SIRT inhibitors (i.e. sirtinol, EX527, AGK2 and AK1) can limit NPC cell proliferation, only the SIRT2 specific inhibitors AGK2 and AK1 function cooperatively with Lapatinib, supporting the idea that SIRT2 specifically modulates Lapatinib response and resistance. The gene discussed is SIRT2; the disease is nasopharyngeal carcinoma.