In clonogenic assays, both SIRT2-inhibitors displayed additive effects on Lapatinib in NPC cell lines (2 way-ANOVA, ****P < 0.0001, for all except **P < 0.0033 for AK1 in 6-10B), further reducing the overall clonogenic survival of Lapatinib-treated cells (Fig. 6b). The gene discussed is SIRT2; the disease is nasopharyngeal carcinoma.