ADIPOQ and migraine disorder: These mechanisms may include affecting serotoninergic dysfunction, neuronal excitability, levels of factors with a role in migraine pathogenesis (such as Calctonin-Gene-Related-Peptide (CGRP), nitric oxide (NO), adiponectin, and leptin), brain mitochondrial function, neuro-inflammation, hypothalamic function, and platelet aggregation [17, 19–30].