NQO1 and cancer: A critical role of protein dynamics in the mechanisms causing alterations in NQO1 function due to the Pro187Ser polymorphism and other rare cancer-associated mutations, phosphorylation at specific sites as well as the effect of suppressor mutations of the Pro187Ser phenotype have been put forward from experimental and computational studies [5,9,10,14,30,31,32,33,34,36].