NQO1 and cancer: Consequently, even in NQO1apo, the cancer-associated polymorphism Pro187Ser would destabilize the NQO1 monomer, and this effect could easily propagate to the MMI, the FBS and the DBS, thus contributing to explain the low conformational stability of P187S in vitro, its low affinity for FAD and dicoumarol, and its accelerated degradation by the proteasome [9,10,14,22,23,24,25,34].