The results of recent large trials of SGLT2 inhibitors [9,10,11,34,35] seem to indicate the effects of SGLT2 inhibitors on capillaries in the heart and kidney, since the dysfunction of SGLT2-expressing pericytes and mesangial cells is thought to be the cause of HF and DN, as mentioned above. This evidence concerns the gene SLC5A2 and hydrops fetalis.