SLC5A2 and Abnormal renal physiology: Because SGLT2 is functionally expressed in pericytes and mesangial cells and excess glucose and Na+ enters through SGLT2 in diabetic states induce these cellular damages, the preferable effects of SGLT2 inhibitors on HF and renal dysfunctions are probably thought to be independent of the glucose control, and to be mainly derived from direct actions of SGLT2 inhibitors on mesangial cells and pericytes.