In addition, the beneficial effect of FXR ligands on liver inflammation and fibrosis [118,119,120,121], the fact that FXR-deficient mice fed a methionine/choline-deficient diet (MCDD) developed more severe liver injury but a lower degree of steatosis suggests the role of BAs and FXR in maintaining liver homeostasis against metabolic syndrome [127]. The gene discussed is NR1H4; the disease is metabolic syndrome.