They showed that this livestock IFN subtype not only significantly mitigated obesity-associated systemic insulin resistance and adipose inflammation by controlling macrophage polarization, but also had less cytotoxic effect than typical IFN-β subtype, indicating a therapeutic potential through cross-species screening of IFN molecules [46,79,111,112]. The gene discussed is IFNA1; the disease is obesity due to melanocortin 4 receptor deficiency.