IFNB1 and obesity due to melanocortin 4 receptor deficiency: Acting through a non-canonical AKT-mTOR pathway (IFN-β) or an IRF1-indolent process (IFN-λ), these intrinsic or local IFNs signal the expression of some anti-inflammatory and cell growth cytokines including IL-10 and IL-13 to maintain an anti-inflammatory microenvironment, which buffers a homeostatic resistance to meta-inflammation in obesity (Figure 1) [76,77,78].