GCKR and metabolic dysfunction-associated steatotic liver disease: Moreover, a study that surveyed 14 single nucleotide polymorphisms (SNPs) in adolescents with biopsy-proven NAFLD and in control individuals showed that the strongest variants associated with the severity of fibrosis were rs1260326 and rs780094 (both associated with glucokinase (hexokinase 4) regulator (GCKR)) as well as rs659366 (associated with mitochondrial uncoupling protein 2).