THBS1 and Hepatic fibrosis: Although activated HSCs undergo aerobic glycolysis [24], 2D electrophoresis and matrix-assisted laser desorption/ionization-TOF-MS (MALDI-TOF-MS) analysis of serum from eight patients with HBV infection (four with and four without hepatic fibrosis) showed decreased levels of enolase-1, a glycolytic enzyme, and increased levels of thrombospondin-1 in the samples from patients with hepatic fibrosis [85].