In this study, novel findings are: (a) GHR was overexpressed in the tissue of patients with OS compared with osteofibrous dysplasia (Fig. 1); (b) GHR promoted OS cell colony formation and OS tumor growth through the PI3K/AKT pathway (Fig. 2); (c) GHR modulated the proliferation of OS cells in vivo (Fig. 3); (d) GHR enhanced G2/M phase transition and inhibited cell apoptosis; and (e) GHR promoted OS cell migration. The gene discussed is AKT1; the disease is osteofibrous dysplasia.