To determine how CMV productive infection impacts EGFR signaling and pathways downstream of EGFR, we analyzed phosphorylation of EGFR, MEK1/2, ERK1/2, STAT3, PLCγ, and AKT at steady state or following 30 min of EGF stimulation in infected fibroblasts using a EGFR signaling array (PathScan, Cell Signaling Technologies). This evidence concerns the gene STAT3 and infection.