Stably transformed knockdown/rescue cells expressing a mutant Acss2 protein with acidic amino acid substitutions for basic amino acid residues in a putative nuclear localization signal that resulted in cytosol-restriction, hereby referred to as ED Acss2 protein, displayed impaired HIF-2 dependent signaling and a blunted ability for flank tumor growth[5, 8]. This evidence concerns the gene ACSS2 and neoplasm.