First, these 2 proteins can induce cancer cell proliferation, apoptosis and migration through regulating various signaling pathways, such as the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathways, and the E2F-retinoblastoma protein-p16 pathway.[15,48] Second, the expression of these 2 proteins can be suppressed by certain miRNAs, which may provide candidate novel molecular targets for precise cancer treatment.[26,49] Finally, some cancer-related proteins or enzymes are involved in regulating the expression of KIF2A and KIF20A. This evidence concerns the gene KIF2A and cancer.