KIF2A and lung cancer: For instance, down-regulation of KIF2A in gastric cancer inhibits tumor cell invasion through suppressing the expression of Membrane type 1-matrix metalloproteinase.[50] Besides, forkhead box protein M1 can enhance the radiation resistance of lung cancer through inducing KIF20A expression.[51] Several studies have been carried out to explore the biological functions of KIF2A and KIF20A in various tumor cells, but the molecular mechanisms underlying these 2 proteins and cancer progression remain unclear so far.