Such patients are refractory to immunosuppressive treatment, even if anti-tumor necrosis factor (TNF) inhibitors are used.[2] However, some patients received hematopoietic stem cell transplantation (HSCT) to treat both BD and MDS, resulting in complete remission.[3,4] Herein, we present the case of a patient with intestinal BD associated with trisomy 8-positive MDS who received abdominal surgery for ileocecal perforation followed by peripheral blood cell transplantation (PBSCT). Here, TNF is linked to myelodysplastic syndrome.