In human medicine, tissue glucose concentration nadirs in muscle have been reported to be delayed in time and lower in magnitude relative to glucose concentrations in adipose tissue and blood, especially during insulin‐induced hypoglycemia.46, 47 Decreased thickness of the SC adipose tissue layer may result in closer sensor proximity to the underlying muscle tissue and, consequently, in inaccurate glucose concentration results. The gene discussed is INS; the disease is Hypoglycemia.