The importance of MUTYH gene mutation in colorectal cancer was confirmed by AL-Tassan et al. for the first time, people from a family who have two-allelic mutation in the MUTYH gene have a autosomal form of adenomatous familial polyposis,when analyzing the cancerous tissues of these patients, there was a strong indication of the conversion of G: C> T: A into commonly mutated genes of CRC (APC, K-RAS). Here, MUTYH is linked to Familial adenomatous polyposis.