Expression of the pro‐inflammatory cytokines TNF‐α, IL‐6, and chemokines like MIP‐2 and KC mRNA in lung tissues was increased in CLP‐induced sepsis and was significantly reduced with miRNA 130b‐3p mimic treatment by 63, 56, 75, and 47.5%, respectively (Fig 6F–I). The gene discussed is CALCA; the disease is Sepsis.