For example, SEs with multiple constituents in MYC-locus are located in a non-overlapping manner among different cell types (8,115): CRC tumors generally harbor an SE of MYC ∼300 kb upstream of its promoter, while in acute leukemia an SE 1.7 Mb downstream of the TSS plays a primary role of activating c-MYC expression (138,139). The gene discussed is MYC; the disease is acute leukemia.