In a multivariate Cox proportional hazard regression analysis adjusted for variables that in a univariate regression analysis had p-value 0.1 or less (age, NYHA class, atrial fibrillation and GFR class) NT-proBNP remained highly associated with all-cause mortality with HR 1.48 (CI 1.16–1.90), p-value =0.0001 (Table 4). This evidence concerns the gene NPPB and atrial fibrillation.