In a multivariate Cox proportional hazard regression analysis adjusted for variables which in the univariate regression analysis had a p-value of 0.1 or lower (age, NYHA class, atrial fibrillation and GFR class) NT-proBNP remained highly associated with all-cause mortality with HR 1.83 (95% CI 1.38–2.44) p-value <0.0001 (Table 3). Here, NPPB is linked to atrial fibrillation.